Download MendeleyHuman polymerase theta helicase positions DNA microhomologies for double-strand break repair
Zerio, C.J., Bai, Y., Sosa-Alvarado, B.A., Guzi, T., Lander, G.C.To be published.
9BH6
Human DNA polymerase theta helicase domain tetramer in the apo form
- PDB DOI: https://doi.org/10.2210/pdb9BH6/pdb
- EM Map EMD-44534: EMDB EMDataResource
- Classification: DNA BINDING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2024-04-19 Released: 2024-05-01
- Funding Organization(s): National Institutes of Health/National Cancer Institute (NIH/NCI), National Institutes of Health/National Center for Research Resources (NIH/NCRR)
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.30 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| DNA polymerase theta | 893 | Homo sapiens | Mutation(s): 0 Gene Names: POLQ, POLH EC: 3.6.4.12 (PDB Primary Data), 2.7.7.7 (PDB Primary Data), 2.7.7.49 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O75417 (Homo sapiens) Explore O75417 Go to UniProtKB: O75417 | |||||
PHAROS: O75417 GTEx: ENSG00000051341 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | O75417 | ||||
Sequence AnnotationsExpand | |||||
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Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.30 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
| Task | Software Package | Version |
|---|---|---|
| MODEL REFINEMENT | PHENIX | 1.20.1 |
| RECONSTRUCTION | cryoSPARC | 4.3 |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-05-01 Deposition Author(s): Zerio, C.J., Lander, G.C.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Cancer Institute (NIH/NCI) | United States | F32CA288144 |
| National Institutes of Health/National Center for Research Resources (NIH/NCRR) | United States | S10OD032467 |
Revision History (Full details and data files)
- Version 1.0: 2024-05-01
Type: Initial release
