Download MendeleyHuman dUTPase in complex with a potent proteinaceous inhibitor (Stl)
Kohegyi, B.K., Nyiri, K., Vertessy, B.G.To be published.
8C8I
Human dUTPase in complex with a potent proteinaceous inhibitor (Stl)
- PDB DOI: https://doi.org/10.2210/pdb8C8I/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens, Staphylococcus aureus
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2023-01-20 Released: 2024-05-01
- Funding Organization(s): Hungarian National Research, Development and Innovation Office
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 3.20 Å
- R-Value Free: 0.251
- R-Value Work: 0.193
- R-Value Observed: 0.196
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial | 128 | Homo sapiens | Mutation(s): 0 Gene Names: DUT EC: 3.6.1.23 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P33316 (Homo sapiens) Explore P33316 Go to UniProtKB: P33316 | |||||
PHAROS: P33316 GTEx: ENSG00000128951 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P33316 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Orf20 | 147 | Staphylococcus aureus | Mutation(s): 0 |  | |
UniProt | |||||
Find proteins for Q9F0J8 (Staphylococcus aureus) Explore Q9F0J8 Go to UniProtKB: Q9F0J8 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9F0J8 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| MG (Subject of Investigation/LOI) Query on MG | G [auth A] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 3.20 Å
- R-Value Free: 0.251
- R-Value Work: 0.193
- R-Value Observed: 0.196
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 78.45 | α = 90 |
| b = 82.66 | β = 90 |
| c = 139.6 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| SCALA | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-05-01 Deposition Author(s): Kohegyi, B.K., Nyiri, K., Vertessy, B.G.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Hungarian National Research, Development and Innovation Office | Hungary | PD134324 |
Revision History (Full details and data files)
- Version 1.0: 2024-05-01
Type: Initial release
