Annotations: 9AYG

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Voltage-dependent T-type calcium channel subunit alpha-1H	calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity low voltage-gated calcium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity low voltage-gated calcium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity high voltage-gated calcium channel activity scaffold protein binding protein binding binding cation binding ion binding metal ion binding small molecule binding	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction blood circulation cellular biosynthetic process steroid metabolic process heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction blood circulation cellular biosynthetic process steroid metabolic process organic hydroxy compound metabolic process lipid biosynthetic process alcohol metabolic process cortisol metabolic process organic substance metabolic process cellular ketone metabolic process organic substance biosynthetic process small molecule metabolic process primary alcohol biosynthetic process steroid biosynthetic process steroid hormone biosynthetic process tertiary alcohol metabolic process olefinic compound biosynthetic process small molecule biosynthetic process cellular metabolic process primary metabolic process cortisol biosynthetic process glucocorticoid metabolic process glucocorticoid biosynthetic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process tertiary alcohol biosynthetic process olefinic compound metabolic process metabolic process cellular process ketone biosynthetic process lipid metabolic process primary alcohol metabolic process cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to stimulus response to potassium ion response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular response to potassium ion developmental process muscle structure development animal organ development anatomical structure development muscle organ development response to organic substance response to endogenous stimulus cellular response to endogenous stimulus response to hormone cellular response to organic substance cellular response to hormone stimulus transmembrane transport localization transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport import into cell calcium ion transmembrane import into cytosol monoatomic ion transmembrane transport import across plasma membrane inorganic cation import across plasma membrane calcium ion transport metal ion transport monoatomic cation transmembrane transport calcium ion import across plasma membrane inorganic ion import across plasma membrane monoatomic ion transport calcium ion import calcium ion import into cytosol monoatomic cation transport calcium ion transmembrane transport sexual reproduction regulation of reproductive process reproductive process fertilization positive regulation of biological process positive regulation of acrosome reaction acrosome reaction regulation of acrosome reaction single fertilization positive regulation of reproductive process regulation of biological quality regulation of membrane potential mineralocorticoid biosynthetic process aldehyde biosynthetic process C21-steroid hormone metabolic process mineralocorticoid metabolic process aldosterone metabolic process cellular aldehyde metabolic process hormone biosynthetic process aldosterone biosynthetic process regulation of hormone levels C21-steroid hormone biosynthetic process hormone metabolic process cellular developmental process myoblast fusion cell-cell fusion muscle cell differentiation myotube differentiation syncytium formation by plasma membrane fusion anatomical structure morphogenesis cell differentiation anatomical structure formation involved in morphogenesis syncytium formation striated muscle cell differentiation muscle contraction muscle system process	membrane cellular anatomical entity cell periphery plasma membrane protein-containing complex plasma membrane protein complex voltage-gated calcium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex calcium channel complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005821	Ion transport domain	Domain
A	IPR005445	Voltage-dependent calcium channel, T-type, alpha-1 subunit	Family
A	IPR043203	Voltage-gated cation channel calcium and sodium	Family
A	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O95180	childhood absence epilepsy hyperaldosteronism, familial, type IV absence epilepsy epilepsy epilepsy, childhood absence, susceptibility to, 6 juvenile absence epilepsy primary aldosteronism epilepsy, childhood absence, susceptibility to, 1 hypertensive disorder lung carcinoma osteosarcoma psoriasis autism intellectual disability malignant mesothelioma childhood absence epilepsy hyperaldosteronism, familial, type IV absence epilepsy epilepsy epilepsy, childhood absence, susceptibility to, 6 juvenile absence epilepsy primary aldosteronism epilepsy, childhood absence, susceptibility to, 1 hypertensive disorder lung carcinoma osteosarcoma psoriasis autism intellectual disability malignant mesothelioma peripheral nervous system disease autism spectrum disorder

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.